Plaque Size and Composition in Apolipoprotein E Knockout Mice Transfer of Endothelial Progenitor and Bone Marrow Cells Influences Atherosclerotic
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Jacob George, Arnon Afek, Anastasia Abashidze, Haim Shmilovich, Varda Deutsch, Juri Plaque Size and Composition in Apolipoprotein E Knockout Mice Transfer of Endothelial Progenitor and Bone Marrow Cells Influences Atherosclerotic Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2005 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000188554.49745.9e 2005; 2005;25:2636-2641; originally published online September 29, Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/25/12/2636 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice.
OBJECTIVE Recent clinical trials use cell therapy with bone marrow (BM) cells or endothelial progenitor cells (EPCs) for ischemic syndromes. We explored the effect of BM cell- or spleen cell-derived EPC transfer on plaque size and stability markers in the apolipoprotein E knockout (apoE KO) mouse model. METHODS AND RESULTS ApoE KO mice aged 10 weeks served as recipients. Labeled BM cells and ...
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AIM Clopidogrel is a widely used anti-thrombotic for the prevention of stent thrombosis and cardiovascular events in patients with coronary atherosclerosis. Clopidogrel has been shown to exhibit anti-inflammatory effects that are related to the attenuated activation of platelets. Atherosclerosis is a complex process in which the immune system and the endothelium appear to play a prominent role....
متن کاملSmooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice.
BACKGROUND Signs of preceding episodes of plaque rupture and smooth muscle cell (SMC)-mediated healing are common in atherosclerotic plaques, but the source of the healing SMCs is unknown. Recent studies suggest that activated platelets adhering to sites of injury recruit neointimal SMCs from circulating bone marrow-derived progenitor cells. Here, we analyzed the contribution of this mechanism ...
متن کاملPanax notoginseng saponins promote endothelial progenitor cell mobilization and attenuate atherosclerotic lesions in apolipoprotein E knockout mice.
BACKGROUND Endothelial progenitor cells (EPCs) derived from the bone marrow (BM) play a key role in the homeostasis of vascular repair by enhanced reendothelialization. Panax notoginseng saponins (PNS), a highly valued traditional Chinese medicine, has been shown to reduce morbidity and mortality from coronary artery disease. The present research was designed to explore the contribution of prog...
متن کاملCaspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice
Apoptosis of macrophages and vascular smooth muscle cells (VSMCs) in advanced atherosclerotic plaques contributes to plaque progression and instability. Caspase-3, a key executioner protease in the apoptotic pathway, has been identified in human and mouse atherosclerotic plaques but its role in atherogenesis is not fully explored. We therefore investigated the impact of caspase-3 deletion on at...
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تاریخ انتشار 2005